中新网北京8月13日电 近日，中国工程院院士陈薇在《中国工程科学》刊发《表征生物学》一文，提出了“表征生物学”这一概念，以应对现代生物学面临的一个巨大挑战：如何在解析复杂生物学过程的同时，准确而又简约地呈现每个个体的特性以及个体之间的共性。
陈薇院士在文章中指出，表征生物学是指将复杂的生物学过程通过多维度研究和精确解析，以简约概念和特征性方式量化呈现的学科。这一概念的核心在于对生物学数据的全息获取、深度挖掘、特征识别、提炼分类、编码定量和表征展示，旨在揭示生物体在分子、细胞、组织和个体等不同层次上的特征和规律。
表征生物学强调跨学科融合，它不仅有助于揭示个体间的生物学差异及其对健康状态的影响，还能为个性化医学提供支持。在感染性疾病防治方面，表征生物学能够为病原体感染性疾病提供深入调查，全面描述疾病进展过程中与病原体感染和机体免疫反应相关的动态变化和免疫调节机制。
在癌症诊断与治疗方面，表征生物学通过基因组学和蛋白质组学分析，确定关键突变基因，识别关键的致病分子及其功能，为个性化治疗和预防方案的制定提供科学依据。
此外，表征生物学还能够帮助解码衰老，整合分散在分子、细胞、组织、个体等不同层面的衰老特征信息，在一个全新的维度上促进衰老精确定量和精准分型，制定个性化的衰老干预方案。
陈薇院士的文章为表征生物学的发展提供了理论基础和实践路径，对于推动现代生物学的发展具有重要意义。随着研究的深入，表征生物学有望成为解决生物学领域复杂问题的关键工具。
英语如下：
News Title: “Chen Wei Advocates ‘Phenomics’ to Solve Modern Biology Challenges”
Keywords: Phenomics, Biology, Challenge
News Content:
BEIJING, Aug. 13 (Xinhua) — Recently, Chen Wei, a member of the Chinese Academy of Engineering, published an article titled “Phenomics” in the journal “Chinese Engineering Science,” proposing the concept of “phenomics” to address a significant challenge facing modern biology: how to accurately and concisely present the characteristics of each individual and the commonalities among them while unraveling complex biological processes.
In her article, Chen Wei, a member of the Chinese Academy of Engineering, points out that phenomics refers to the discipline of quantifying complex biological processes through multidimensional research and precise analysis, presented in a concise and characteristic manner. The core of this concept lies in acquiring a holographic grasp of biological data, conducting deep mining, identifying features, refining classification, encoding quantification, and presenting representation, aiming to reveal the characteristics and laws of biological organisms at different levels, including molecules, cells, tissues, and individuals.
Phenomics emphasizes interdisciplinary integration, which not only helps reveal biological differences among individuals and their impact on health status but also supports personalized medicine. In the prevention and treatment of infectious diseases, phenomics can provide in-depth investigation into pathogen-related diseases, comprehensively describing dynamic changes and immune regulation mechanisms related to pathogen infection and host immune responses during the disease progression.
In the diagnosis and treatment of cancer, phenomics can determine critical mutated genes and identify key pathogenic molecules and their functions through genomics and proteomics analysis, providing scientific basis for the formulation of personalized treatment and prevention plans.
Furthermore, phenomics can assist in deciphering aging, integrating scattered information on aging characteristics across different levels, including molecules, cells, tissues, and individuals, promoting precise quantification and classification of aging in a new dimension, and formulating personalized interventions for aging.
Chen Wei’s article provides a theoretical foundation and practical path for the development of phenomics, which is of great significance for advancing modern biology. With further research, phenomics is expected to become a key tool in solving complex biological problems.
【来源】http://www.chinanews.com/life/2024/08-13/10268258.shtml
Views: 2