正文：
近日，来自国防科技大学、西湖大学、浙江大学和之江实验室的研究团队合作提出了名为TriLoS的设计方法，这一创新成果已在国际顶级期刊《Cell》上发表。该研究通过多层基因表达调控网络在细胞内实现了组合逻辑线路的高效设计与构建，为生物计算领域带来了新的突破。
细胞被比作生物体内的“微型计算机”，每时每秒都在接收、分析和处理来自环境中的信息。研究人员通过分析细胞内基因表达调控的层次结构，发现可以将细胞内的基因表达调控抽象为类似于电子电路中的三态门结构。在此基础上，他们成功构建了多种基本逻辑单元，如BUFIF1、NOTIF1、BUFIF0和NOTIF0，并展示了其在细胞中的良好性能。
与传统的逻辑基因线路设计方式相比，TriLoS设计方法展现出了更强的模块化和可拓展性。研究人员利用这一方法，高效地实现了异或逻辑（XOR）等复杂组合逻辑线路的构建。这一创新不仅提高了哺乳动物细胞的“可编辑空间”，也为更高效地设计生物计算元器件奠定了基础，有望推动细胞计算领域的进一步发展。
这一研究成果标志着中国在生物计算领域取得了重要进展，为未来开发基于生物系统的计算机提供了新的可能性。随着研究的深入，生物计算元器件的设计方法将更加成熟，有望在医疗、农业、环境监测等领域发挥重要作用。
英语如下：
News Title: “Cell Programming Breakthrough: Four Universities Create Biological Calculator”
Keywords: Cell Computing, Biomolecular Components, Combinational Logic
News Content:
Title: Four Chinese Universities Develop Novel Cell Computing Method and Publish in Top International Journal Cell
Recent research from a team of scientists from National University of Defense Technology, Lake University, Zhejiang University, and the Hangzhou Institute for Advanced Study has proposed a design method named TriLoS, which has been published in the prestigious international journal Cell. This innovative study has successfully implemented efficient design and construction of combinational logic circuits within cells through multi-layer gene expression regulation networks, marking a new breakthrough in the field of biological computing.
Cells are likened to the “microcomputers” within the body, continuously receiving, analyzing, and processing information from the environment every second. By analyzing the hierarchical structure of gene expression regulation within cells, researchers discovered that the regulation of gene expression within cells could be abstracted into a structure similar to three-state gates in electronic circuits. Building on this discovery, they successfully constructed various basic logic units, including BUFIF1, NOTIF1, BUFIF0, and NOTIF0, and demonstrated their good performance within cells.
Compared to traditional methods for designing logical gene circuits, the TriLoS design method demonstrates stronger modularity and scalability. Researchers have efficiently implemented the construction of complex combinational logic circuits, such as the exclusive OR (XOR) logic, using this method. This innovation not only enhances the “editing space” of mammalian cells but also lays the groundwork for more efficient design of biomolecular computing components, promising to further develop the field of cell computing.
This research achievement signifies an important progress in China’s field of biological computing and offers new possibilities for the development of biological-based computing systems. As research deepens, the design methods for biomolecular computing components are expected to become more mature, and they are poised to play a significant role in medical, agricultural, and environmental monitoring fields.
【来源】https://www.jiqizhixin.com/articles/2024-08-01-9
Views: 1