**两种关键蛋白质揭示中风复发风险，科研新发现提供治疗新方向**
近日，美国心脏协会期刊《中风》发表了重要研究成果，指出两种蛋白质——CCL27和TNFRSF14——可能与中风患者的二次中风或其他重大心血管不良事件（MACE）有关联。这项研究由美国科研团队进行，针对曾经历过急性缺血性卒中（AIS）或短暂性脑缺血发作（TIA）的患者，揭示了炎症在中风后发生MACE的潜在影响因素。
中风，尤其是急性缺血性卒中和短暂性脑缺血发作，常常给患者带来巨大的健康风险。已有研究显示，炎症在这些疾病的进展中扮演着重要角色。在这次研究中，科学家们发现，CCL27和TNFRSF14这两种蛋白质的活性增强，可能促使炎症反应加剧，从而增加患者二次中风或其他心血管事件的风险。
科研人员通过全基因组关联研究（GWAS）分析了来自两个大型生物库的遗传信息和病史数据，总计涉及93422名中风患者，其中51929人随后出现了重大心血管不良事件，45120人随后出现了急性缺血性卒中。研究结果显示，CCL27和TNFRSF14的高表达与二次中风风险显著相关，但与初次中风无关，表明这两类蛋白质可能在中风后的炎症反应中发挥关键作用。
这一发现对于中风患者的后续治疗和预防具有重要意义。研究结果提示，针对CCL27和TNFRSF14的药物干预可能成为开发新型中风预防和治疗策略的潜在靶点。未来，科学家们将深入研究这些蛋白质在中风复发过程中的具体作用机制，并探索针对它们的治疗方法，以期为中风患者提供更有效的治疗方案，减少二次中风和其他心血管事件的发生风险。
随着研究的深入，我们期待这一科研成果能为中风防治领域带来新的突破，为中风患者带来更光明的康复前景。
英语如下：
**”Two Key Proteins Linked to Stroke Recurrence, Research Unveils New Drug Targets”**
In a significant development for stroke patients, a recent study published in the American Heart Association journal, *Stroke*, has identified two proteins, CCL27 and TNFRSF14, that may be associated with the recurrence of strokes or major adverse cardiovascular events (MACE) in patients who have experienced an acute ischemic stroke (AIS) or a transient ischemic attack (TIA). Conducted by a US research team, the study focused on patients who had undergone AIS or TIA, revealing the potential impact of inflammation on MACE following a stroke.
Acute ischemic stroke and transient ischemic attack often pose significant health risks to patients. Research has shown that inflammation plays a crucial role in the progression of these diseases. In this study, scientists found that an enhanced activity of CCL27 and TNFRSF14 could intensify the inflammatory response, thereby increasing the risk of a secondary stroke or other cardiovascular events in patients.
Researchers analyzed genetic information and medical histories from two large biobanks using a Genome-Wide Association Study (GWAS), involving 93,422 stroke patients, of which 51,929 subsequently experienced major cardiovascular adverse events, and 45,120 had a subsequent acute ischemic stroke. The findings showed a significant correlation between the high expression of CCL27 and TNFRSF14 and the risk of secondary stroke, but not with the initial stroke, suggesting that these two proteins may play a pivotal role in the inflammatory response following a stroke.
This discovery holds significant implications for the post-stroke treatment and prevention of stroke patients. The study results suggest that interventions targeting CCL27 and TNFRSF14 could be potential targets for the development of new stroke prevention and treatment strategies. In the future, scientists will delve deeper into the specific mechanisms by which these proteins contribute to stroke recurrence and explore treatment options aimed at them, aiming to provide more effective treatment protocols for stroke patients and reduce the risk of secondary strokes and other cardiovascular events.
As research continues, we look forward to this scientific achievement bringing new breakthroughs to the field of stroke prevention and treatment, offering brighter prospects for recovery to stroke patients.
【来源】http://www.chinanews.com/life/2024/07-25/10256893.shtml
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