深圳研究团队成功建立阿尔茨海默病新型猴模型
中国科学院深圳先进技术研究院（简称“深圳先进院”）于7月12日发布了一项最新研究成果，该研究团队成功建立了精准模拟家族性阿尔茨海默病致病突变的新型猴模型。这一突破性进展在国际期刊《Alzheimer’s & Dementia》上得到了发表，标志着阿尔茨海默病研究领域的一项重要进展，为深入了解疾病机制和开发潜在治疗策略提供了宝贵资源。
阿尔茨海默病，全称为阿尔茨海默病性痴呆，是一种进行性的神经退行性疾病，主要影响老年人的认知功能，包括记忆、思考和日常生活能力。目前，全球范围内，阿尔茨海默病的发病率和死亡率逐年上升，成为全球公共卫生的一大挑战。
深圳先进院的研究团队通过精确地模拟家族性阿尔茨海默病的致病突变，成功构建了新型猴模型。这一模型能够精准地反映人类阿尔茨海默病的病理特征，包括神经元损伤、β淀粉样蛋白沉积和Tau蛋白异常磷酸化等。通过这一模型，研究团队能够更深入地探索阿尔茨海默病的发病机制，以及不同治疗策略的效果，从而为开发有效的预防和治疗方法提供科学依据。
这一研究成果不仅对阿尔茨海默病的基础研究具有重要意义，也为未来可能的临床应用铺平了道路。通过进一步研究，科学家们有望找到延缓或逆转阿尔茨海默病进展的新途径，为患者及其家庭带来希望。深圳先进院的研究团队将继续致力于这一领域的探索，与全球的科研机构和医疗机构合作，共同推进阿尔茨海默病的科学研究和临床治疗的发展。
英语如下：
News Title: “Shenzhen Research Team Overcomes Alzheimer’s, Successfully Cultivates Novel Primate Model”
Keywords: Shenzhen Research Team, Alzheimer’s Disease Model, Successful Establishment
News Content: Shenzhen Research Team Successfully Establishes Novel Primate Model for Alzheimer’s Disease
On July 12th, the Shenzhen Institutes of Advanced Technology (SIAT), a branch of the Chinese Academy of Sciences, announced a groundbreaking study. The team successfully developed a novel primate model that precisely mimics the pathogenic mutations associated with familial Alzheimer’s disease. This significant achievement was published in the international journal “Alzheimer’s & Dementia,” marking a major advancement in the field of Alzheimer’s disease research, and providing invaluable resources for a deeper understanding of the disease’s mechanisms and potential therapeutic strategies.
Alzheimer’s disease, formally known as Alzheimer’s disease dementia, is a progressive neurodegenerative disorder that primarily affects cognitive functions in the elderly, including memory, thinking, and daily living abilities. With the global incidence and mortality rates of Alzheimer’s disease on the rise, it has become a significant public health concern worldwide.
The Shenzhen advanced research team successfully constructed a novel primate model by precisely simulating the pathogenic mutations of familial Alzheimer’s disease. This model accurately reflects the pathological characteristics of human Alzheimer’s disease, including neuronal damage, β-amyloid deposition, and abnormal phosphorylation of tau protein. Through this model, the research team can delve deeper into the mechanisms of Alzheimer’s disease and the effects of various treatment strategies, thereby providing scientific foundations for the development of effective preventive and treatment approaches.
This research not only holds significant importance for the basic research of Alzheimer’s disease but also lays the groundwork for potential future clinical applications. With further research, scientists are expected to find new pathways to slow or reverse the progression of Alzheimer’s disease, offering hope to patients and their families. The Shenzhen advanced research team will continue to explore this field, collaborating with global research institutions and medical organizations to advance the scientific research and clinical treatment of Alzheimer’s disease.
【来源】http://www.chinanews.com/life/2024/07-12/10250374.shtml
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