科技日报讯（记者张佳欣）近日，日本东京理科大学的研究团队从人类皮肤上常见的细菌——结核硬脂酸棒状杆菌中，发现了一种有前景的酪氨酸酶抑制剂。这种抑制剂能够有效抑制黑色素合成，从而达到安全美白皮肤的效果。相关研究成果已发表在《国际分子科学》杂志上。
酪氨酸酶是人体内产生黑色素的关键酶，当紫外线照射皮肤时，酪氨酸酶活性增加，导致黑色素过度生成，引发皮肤变黑。因此，酪氨酸酶抑制剂在化妆品行业中得到了广泛应用，用以美白皮肤。然而，一些传统的美白成分如对苯二酚，因其对皮肤有毒性，已被限制使用。
研究人员通过筛选100多种皮肤细菌，发现结核硬脂酸棒状杆菌能够产生一种强效的酪氨酸酶抑制剂——环(脯氨酸—酪氨酸)。实验表明，这种化合物对人体细胞无毒，且具有抗菌、抗氧化和抗癌等活性，具有广阔的应用前景。
尽管这一发现令人兴奋，但要将其转化为实际的美白产品，还需要进行更多研究，包括安全性评估、剂量确定以及临床实验等。研究人员表示，随着研究的深入，这种从天然细菌中提取的美白成分有望为消费者提供一种更加安全、有效的选择。
英语如下：
News Title: “New Discovery of Bacteria: A Safe Whitening Agent for Skin”
Keywords: Tyrosinase, Whitening, Safety
News Content:
Science and Technology Daily, (Reporter Zhang Jiaxin) Recently, a research team from Tokyo University of Science discovered a promising tyrosinase inhibitor from a common skin bacterium, Mycobacterium linens, which is found on human skin. This inhibitor can effectively suppress melanin synthesis, thus achieving a safe and effective whitening effect on the skin. The related research findings have been published in the journal “International Molecular Science.”
Tyrosinase is a key enzyme in the human body that produces melanin. When the skin is exposed to ultraviolet light, the activity of tyrosinase increases, leading to excessive production of melanin and causing the skin to darken. Therefore, tyrosinase inhibitors are widely used in the cosmetics industry for skin whitening. However, some traditional whitening ingredients, such as hydroquinone, have been restricted due to their toxicity to the skin.
The researchers screened over 100 types of skin bacteria and found that Mycobacterium linens can produce a potent tyrosinase inhibitor called cyclo(proline-tyrosine). Experiments showed that this compound is non-toxic to human cells and has antibacterial, antioxidant, and anticancer activities, suggesting a broad application potential.
Although this discovery is exciting, more research is needed to translate it into a practical whitening product, including safety assessments, determination of dosage, and clinical trials. The researchers stated that as the research progresses, this natural whitening ingredient extracted from bacteria has the potential to offer consumers a safer and more effective option.
【来源】http://www.chinanews.com/life/2024/08-09/10266311.shtml
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