【中新社香港7月8日电】（记者 韩星童）香港大学医学院中医药学院研究团队近期发表的一项突破性研究成果，揭示了一种意想不到的健康风险——脂肪肝与乳腺癌之间的潜在联系。该团队发现，非酒精性脂肪肝（俗称脂肪肝）患者的肝脏会异常分泌一种名为“成纤维细胞生长因子21”（FGF21）的因子，这可能加速乳腺癌肿瘤的生长，从而对患者健康构成威胁。
脂肪肝通常与代谢综合征相关，包括肥胖、高血糖和高血压，这些因素都会增加乳腺癌的风险。然而，这项新发现揭示了脂肪肝在乳腺癌恶化过程中可能扮演的直接角色。FGF21是一种在肝脏细胞中被激活时产生的蛋白质，它在调节能量代谢、炎症反应和细胞增殖中发挥关键作用。研究团队通过实验发现，FGF21的过量分泌能够促进乳腺癌细胞的增殖和肿瘤的生长速度。
这一发现对于乳腺癌患者和脂肪肝患者而言具有重要意义。它不仅强调了改善生活习惯、控制体重和预防脂肪肝的重要性，也为乳腺癌的治疗提供了新的方向。未来的研究将致力于探索如何通过靶向FGF21的机制来抑制乳腺癌肿瘤的生长，从而为患者提供更有效的治疗策略。
香港大学医学院中医药学院院长表示：“这一发现不仅丰富了我们对脂肪肝和乳腺癌之间复杂相互作用的理解，也为开发新的治疗策略提供了理论基础。我们期待未来的研究能够进一步揭示这一机制的细节，并为患者带来实质性的健康益处。”
总的来说，这项研究不仅对乳腺癌和脂肪肝的患者群体具有重要意义，也为医学界提供了新的研究方向，有望在未来推动相关疾病的预防和治疗取得突破性进展。
英语如下：
News Title: “Fatty Liver May Speed Up Breast Cancer Progression: HKU’s New Research Reveals Shocking Link”
Keywords: fatty liver, breast cancer, progression
News Content: [Hong Kong, July 8] – (Reporter: Han Xingtong) – A groundbreaking study recently published by the Chinese University of Hong Kong’s School of Chinese Medicine has unveiled an unexpected health risk – a potential connection between fatty liver and breast cancer. The research team found that patients with non-alcoholic fatty liver disease (often referred to as fatty liver) have abnormal secretion of a factor called “Fibroblast Growth Factor 21” (FGF21) by their liver. This could accelerate the growth of breast cancer tumors, posing a threat to patient health.
Fatty liver is typically associated with metabolic syndrome, including obesity, high blood sugar, and high blood pressure, all of which increase the risk of breast cancer. However, this new discovery highlights a direct role that fatty liver may play in the progression of breast cancer. FGF21 is a protein produced in liver cells when they are activated, playing a crucial role in regulating energy metabolism, inflammation, and cell proliferation. The research team’s experiments revealed that excessive secretion of FGF21 can promote the proliferation of breast cancer cells and the growth rate of tumors.
This finding is significant for both breast cancer patients and those with fatty liver. It underscores the importance of improving lifestyle habits, managing weight, and preventing fatty liver. It also opens new directions for breast cancer treatment. Future research will focus on exploring how to target the mechanism of FGF21 to inhibit the growth of breast cancer tumors, offering more effective treatment strategies for patients.
The dean of the Chinese Medicine College at the Chinese University of Hong Kong stated, “This discovery not only enriches our understanding of the complex interactions between fatty liver and breast cancer, but also provides a theoretical basis for the development of new treatment strategies. We look forward to future research that will further uncover the details of this mechanism and bring tangible health benefits to patients.”
In summary, this study is of great significance for the patient populations of breast cancer and fatty liver, and it also provides new research directions for the medical community, with the potential to drive breakthroughs in the prevention and treatment of related diseases in the future.
【来源】http://www.chinanews.com/life/2024/07-08/10247912.shtml
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