浙江中医药大学基础医学院的一支科研团队近日在国际著名学术期刊上发表了一篇研究型论文，揭示了红斑狼疮免疫失衡的新机制，为该疾病的治疗提供了新的靶点。
据了解，红斑狼疮是一种自身免疫性疾病，患者的免疫系统会攻击自身的组织，导致多系统受累。然而，这种疾病的发病机制至今尚不明确。这次，浙江中医药大学的科研团队通过深入研究，首次发现了拟泛素化修饰在调控系统性红斑狼疮中的重要角色。
拟泛素化是一种蛋白质修饰过程，它能够调控细胞内的多种生物学过程。科研团队发现，拟泛素化修饰的改变可能会导致系统性红斑狼疮的发生。这一发现为我们理解红斑狼疮的发病机制提供了新的视角，也为该疾病的治疗提供了新的靶点。
这项研究的成果已经在国际著名学术期刊上发表。浙江中医药大学基础医学院的温成平教授和章云副研究员是这项研究的主要负责人。他们表示，这项研究的结果对于红斑狼疮的治疗具有重要的临床意义，希望能够引起医学界的广泛关注。
英语如下：
Title: Zhejiang University Unveils New Mechanism of Immune Imbalance in Lupus, Potentially Creating a New Target for Treatment
Keywords: 1. Lupus immune imbalance
Content: A research team from the School of Basic Medical Sciences at Zhejiang University of Traditional Chinese Medicine recently published a research paper in an internationally renowned academic journal, unveiling a new mechanism for the immune imbalance in lupus and providing a new target for its treatment.
Lupus is an autoimmune disease where the body’s immune system attacks its own tissues, leading to multisystem involvement. However, the underlying mechanism of this disease remains unclear until now. This time, the research team from Zhejiang University of Traditional Chinese Medicine made a breakthrough by conducting in-depth research and discovering for the first time the important role of ubiquitination modification in regulating systemic lupus erythematosus (SLE).
Ubiquitination is a protein modification process that can regulate various biological processes within cells. The research team found that changes in ubiquitination modification may lead to the development of SLE. This discovery provides a new perspective for understanding the pathogenesis of lupus and offers a new target for its treatment.
The findings of this study have been published in an internationally renowned academic journal. Prof. Wen Chengping and Dr. Zhang Yun, the main researchers behind this study, are from the School of Basic Medical Sciences at Zhejiang University of Traditional Chinese Medicine. They stated that the results of this study have significant clinical implications for the treatment of lupus and hope to attract widespread attention from the medical community.
【来源】http://www.chinanews.com/life/2024/01-17/10147924.shtml
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