中新社北京3月19日电 (记者 孙自法)施普林格·自然旗下专业学术期刊《自然-代谢》最新发表一篇由北京大学科研团队领导完成的癌症研究论文称，研究人员通过一项包含小鼠和人类数据的研究表明，乳酸水平升高或导致癌症发病后恶病质(即疾病相关的体重减轻)的发展。
众所周知，癌症是一种严重威胁人类健康的疾病，其症状之一就是患者在发病后会出现明显的体重减轻，这种现象被称为恶病质。然而，恶病质的发病机制一直是个谜。
北京大学科研团队的研究发现，在癌症患者和小鼠模型中，肿瘤会诱导肌肉和其他组织产生过量的乳酸。这些乳酸不仅会直接导致肌肉萎缩，还会通过抑制食欲和增加能量消耗等方式，进一步促进恶病质的发展。
这一发现对于理解癌症恶病质的发病机制具有重要意义，也为开发新的癌症治疗策略提供了潜在的靶点。未来，通过降低乳酸水平或其对机体的影响，也许能够减缓癌症患者的体重下降，提高他们的生活质量。
英文标题：Title: Study unravels mechanism behind cancer-associated weight loss
英文关键词：Cancer metabolism, cachexia, lactic acid
英文新闻内容：
Beijing, Mar 19 (Xinhua) — A study published in the journal Nature Metabolism by a research team led by Peking University has shed light on the mechanisms underlying cancer-associated weight loss, known as cachexia.
The researchers found that elevated levels of lactic acid, produced by tumors in cancer patients and mouse models, can directly cause muscle wasting and also promote cachexia by suppressing appetite and increasing energy expenditure.
This discovery not only enhances understanding of cachexia but also points to potential targets for developing new cancer treatments. Future interventions aimed at lowering lactic acid levels or its impact on the body could help mitigate weight loss in cancer patients and improve their quality of life.
【来源】http://www.chinanews.com/life/2024/03-19/10183114.shtml
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