虚弱状态增加房颤风险，肥胖和糖尿病人群风险更高
中新网上海3月6日电 (陈静 孙颖) 中国医学专家的最新研究明确了房颤发生的代谢—衰老交互关系，指出人体虚弱可增加房颤风险，对肥胖和糖尿病人群而言，虚弱引发房颤的风险更高。
房颤是心房快速而无序的电活动，是临床上最常见的心律失常，也是导致卒中、心力衰竭和死亡的主要危险因素。近年来，房颤发病率逐年上升，已成为全球公共卫生问题。
研究团队对中国上海地区11万余名无房颤病史的成年人进行了长达10年的随访。研究发现，与非虚弱者相比，虚弱者发生房颤的风险增加36%。进一步分析显示，虚弱与房颤发病风险的关联在肥胖和糖尿病人群中更为明显。与非虚弱者相比，虚弱的肥胖人群发生房颤的风险增加60%，虚弱的糖尿病人群发生房颤的风险增加40%。
研究人员指出，虚弱是一种全身性衰老综合征，其特征是肌肉力量和功能下降。虚弱与多种慢性疾病和不良健康结局有关，包括心血管疾病、认知功能下降和死亡率增加。
研究团队认为，虚弱可能是房颤发病的潜在机制之一。虚弱可能导致心肌功能减弱、心房电重构和炎症反应增强，从而增加房颤的发生风险。肥胖和糖尿病是房颤的重要危险因素，它们可以通过促进炎症、氧化应激和心肌重构等机制进一步加剧虚弱对房颤风险的影响。
该研究提示，虚弱是房颤发病的一个重要危险因素，特别是对于肥胖和糖尿病人群。关注虚弱状态，并采取措施改善虚弱，对于预防房颤具有重要意义。
英语如下：
**Headline:** Frailty Alert: Physical Weakness May Be Silent Culprit in Atrial Fibrillation
**Keywords:** Frailty risk, metabolic aging, obesity, diabetes
**Body:** Frailty increases the risk of atrial fibrillation (AF),and the risk is even higher in people with obesity and diabetes, according to new research from Chinese medical experts.
AF is a rapid and irregular electrical activity in the heart’s upper chambers, and it is the most common type of heart rhythm disorder seen in clinical practice. It is also a major risk factor for stroke, heart failure, and death. In recent years, the incidence of AF has been increasing, making it a global public health concern.
The research team conducted a 10-year follow-up study of more than 110,000 adults in Shanghai, China, who had no history of AF. The study found that frail individuals had a 36% increased risk of developing AF compared with non-frail individuals. Further analysis showed that the association between frailty and AF risk was even more pronounced in people with obesity and diabetes. Frail individuals with obesity had a 60% increased risk ofAF compared with non-frail individuals, while frail individuals with diabetes had a 40% increased risk of AF.
The researchers noted that frailty is a generalized aging syndrome characterized by a decline in muscle strength and function. Frailty is associated with multiple chronic diseases and adverse health outcomes, including cardiovascular disease, cognitive decline, and increased mortality.
The research team believes that frailty may be one of the underlying mechanisms for the development of AF. Frailty may lead to impaired myocardial function, atrial electrical remodeling, and increased inflammation, which could increase the risk of AF. Obesity and diabetes are well-established risk factors for AF, and they may further amplify the effect of frailty on AF risk through mechanisms such as promoting inflammation, oxidative stress, and myocardial remodeling.
The study suggests that frailty is an important risk factor for AF, especially in people with obesity and diabetes. Paying attention to frailty status and taking measures to improve frailty could be important for preventing AF.
【来源】http://www.chinanews.com/sh/2024/03-06/10175213.shtml
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