Breakthrough in Neural Modulation: Chinese Researchers Design High-Efficiency Chip, Advancing Brain-Computer Interfaces
Beijing, China – A collaborative team of researchers from Tianjin University,Beijing University of Technology, Tianjin University of Traditional Chinese Medicine, and Southern University of Science and Technology (SUSTech) has made a significant stride in the field ofneural modulation by designing an eight-channel high-voltage neural stimulation integrated circuit. This innovative chip, featuring biphasic exponential waveform output and charge balancing, drastically enhances the efficiencyand safety of neural stimulation.
The groundbreaking research, published as the inaugural article in the inaugural issue of the journal Neuroelectronics (DOI: 10.55092/neuroelectronics20240001),holds immense promise for advancing the development of neural modulation and implantable devices. The study was led by Professor Yu Hao from the Shenzhen-Hong Kong Institute of Microsystems at SUSTech, Associate Professor Liu Xu from the Department of Electronic Science and Technologyat Beijing University of Technology, and Professor Jin Biao from the School of Automation at Tianjin University.
Addressing Key Challenges in Neural Modulation
The efficiency and safety of stimulation devices have always been paramount concerns in neural modulation applications. Traditional technologies have faced limitations, hindering the development of more effective and reliable brain-computer interfaces. The newly designed high-voltage neural stimulation chip overcomes these obstacles by achieving a 30V high-voltage output, making it particularly suitable for high-impedance electrode-tissue interfaces. This high voltage ensures sufficient charge delivery for robust neural stimulation.
Prioritizing Safety with Active Charge Balancing
To ensure long-term safety, the chip incorporates an innovative active charge balancing mechanism. This mechanism meticulously controls charge transfer within each stimulation cycle, significantly reducing the risk of residual charge accumulation. The researchers achieved a remarkable residual charge level of only 0.77% per cycle. This breakthrough minimizes tissue damage during prolonged neural stimulation, guaranteeing patient safety.
Enhanced Power Efficiency for Extended Use
One of the key highlights of this design is its enhanced power efficiency. By utilizing exponential waveform output instead of the traditional constant current stimulation mode, the power efficiency reaches an impressive 98%. This not only reduces energy consumption but also effectively controls heat dissipation during device operation,laying a solid foundation for future implantable device development.
Rigorous Validation through In Vitro and In Vivo Experiments
The chip underwent rigorous validation through both in vitro and in vivo experiments. In vitro testing involved extensive simulations with different electrode-tissue interface models, successfully demonstrating low residual charge neural stimulation. In vivo experiments,conducted on rats, involved stimulating the vagus nerve and sciatic nerve, resulting in noticeable muscle contractions. These findings confirm the chip’s potential for real-world applications.
A Leap Forward for Brain-Computer Interfaces
This breakthrough in neural modulation technology has the potential to revolutionize the field of brain-computer interfaces. The high-efficiency and safety features of the chip pave the way for the development of more advanced and reliable devices for treating neurological disorders, enhancing human capabilities, and exploring the vast potential of the human brain.
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