据新智元报道，初创公司Profluent近日宣布，完全由AI设计的基因编辑器已经成功编辑了人类细胞中的DNA，标志着世界上首个使用AI从头设计的分子级精确基因编辑器的诞生。
据了解，这个全新的AI系统Profluent，就像ChatGPT能生成诗歌一样，可以让我们编辑自己DNA的微观机制生成蓝图。研究者们利用目前最广泛的基于CRISPR的基因编辑系统数据集，训练了大型语言模型（LLM）。这些LLM产生的蛋白质，将几乎所有天然存在的CRISPR-Cas家族的多样性，扩大了4.8倍。
Profluent公司表示，这一突破性的技术将为基因编辑领域带来巨大的变革。在此之前，基因编辑主要依赖于人工设计和优化，过程复杂、耗时且存在一定的局限性。而Profluent的成功，使得基因编辑的效率和精确性得到了极大的提升。
专家表示，这一成果在理论上具有重要的意义。AI设计的基因编辑器有望在医学、生物科技、农业等多个领域发挥重要作用，例如治疗遗传病、提高农作物产量等。然而，也有声音指出，这项技术在伦理和安全性方面仍需深入探讨。毕竟，基因编辑涉及到生命的根本，一旦出现失误，后果不堪设想。
目前，Profluent公司正在与多家科研机构和生物技术公司合作，进一步研究和开发AI设计的基因编辑技术。未来，我们期待这项技术能在严格遵守伦理和法规的前提下，为人类带来更多的福祉。
英语如下：
**News Title:** “Breakthrough in AI-Designed Gene Editor: Profluent Achieves Precise Editing of Human DNA”
Keywords: AI Gene Editor, Human DNA Editing, CRISPR-Cas Diversity.
**News Content:** ### Startup Profluent Unveils First Gene Editor Completely Designed by AI
According to New Intelligence, startup Profluent recently announced that a gene editor completely designed by AI has successfully edited DNA in human cells, marking the birth of the world’s first molecular-level precise gene editor designed from scratch using AI.
It is understood that this new AI system, Profluent, can generate blueprints for the microscopic mechanisms of editing our own DNA, much like ChatGPT can generate poetry. Researchers have trained a large language model (LLM) using the most extensive dataset of CRISPR-based gene editing systems. The proteins produced by these LLMs have expanded the diversity of almost all naturally occurring CRISPR-Cas families by 4.8 times.
Profluent Company stated that this groundbreaking technology will bring about significant changes to the field of gene editing. Before this, gene editing mainly relied on manual design and optimization, which was complex, time-consuming, and had certain limitations. The success of Profluent has greatly improved the efficiency and precision of gene editing.
Experts say that this achievement is theoretically significant. AI-designed gene editors are expected to play an important role in fields such as medicine, biotechnology, agriculture, and more, such as treating genetic diseases and increasing crop yields. However, some voices have pointed out that ethical and safety issues related to this technology still need to be thoroughly discussed. After all, gene editing involves the fundamental aspects of life, and any mistake could have unimaginable consequences.
Currently, Profluent Company is collaborating with several scientific research institutions and biotechnology companies to further study and develop AI-designed gene editing technologies. In the future, we look forward to this technology bringing more benefits to humanity, on the premise of strictly adhering to ethics and regulations.
【来源】https://mp.weixin.qq.com/s/A3qZHVa0-MxQnkGzsm9KrA
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