中国科学院分子细胞科学卓越创新中心的王红艳研究团队近日取得了一项重大科研突破，该团队与上海大学、复旦大学及上海交通大学的专家学者携手，在国际知名期刊《免疫》(Immunity)上发表了一篇重要论文。该研究揭示了胆固醇代谢如何调控巨噬细胞的抗肿瘤功能，为癌症治疗提供了新的理论基础。
据4月19日中国科学院网站报道，王红艳研究组的最新研究聚焦于25-Hydroxycholesterol（25-羟基胆固醇）这种胆固醇代谢产物。他们发现，25-羟基胆固醇能够直接调节巨噬细胞的活性，进而影响其对肿瘤细胞的攻击能力。这一发现深化了我们对胆固醇代谢与免疫系统相互作用的理解，可能为设计更有效的癌症免疫疗法打开新的途径。
巨噬细胞是免疫系统中的一种关键细胞，具有清除病原体和肿瘤细胞的能力。然而，肿瘤微环境常常能“迷惑”巨噬细胞，使其从抗癌状态转变为促癌状态。王红艳团队的研究表明，通过调控25-羟基胆固醇的水平，可能能够重新激活巨噬细胞的抗癌功能，逆转这种不利情况。
该研究的成果为未来开发针对胆固醇代谢的抗肿瘤策略提供了理论支持，有望在临床实践中改善癌症患者的治疗效果。同时，这也证明了中国科研机构在基础生命科学研究领域的领先地位，以及跨学科合作在解决复杂科学问题上的重要性。
英语如下：
**News Title:** “New Insights into Cholesterol Metabolism: Research Uncovers Anti-Tumor Mechanisms, Paving the Way for Cancer Treatment Innovations”
**Keywords:** Cholesterol Metabolism, Macrophages, Anti-Tumor Mechanisms
**News Content:**
Title: XINHUA HEALTH | Study Reveals New Cholesterol Metabolism Mechanism, Enhancing Macrophage Anti-Tumor Functions
A major scientific breakthrough has been achieved by the Wang Hongyan research team from the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences. Collaborating with experts from Shanghai University, Fudan University, and Shanghai Jiao Tong University, the team published a significant paper in the renowned journal *Immunity*. The research illuminates how cholesterol metabolism regulates the anti-tumor function of macrophages, offering new theoretical foundations for cancer treatment.
As reported on April 19 on the Chinese Academy of Sciences’ website, Wang Hongyan’s group focused on 25-Hydroxycholesterol (25-OH-Cholesterol), a product of cholesterol metabolism. They discovered that 25-OH-Cholesterol directly modulates the activity of macrophages, thereby influencing their capacity to target tumor cells. This finding deepens our understanding of the interplay between cholesterol metabolism and the immune system, potentially opening new avenues for the development of more effective cancer immunotherapies.
Macrophages are crucial cells within the immune system, capable of eliminating pathogens and tumor cells. However, the tumor microenvironment often “hijacks” macrophages, converting them from anti-tumor to pro-tumor states. The Wang Hongyan team’s research suggests that by manipulating 25-OH-Cholesterol levels, the anti-cancer functions of macrophages could be reactivated, reversing this detrimental scenario.
These findings lend theoretical support to the development of anti-tumor strategies targeting cholesterol metabolism, with the potential to enhance treatment outcomes for cancer patients in clinical practice. Furthermore, this research underscores China’s leading position in fundamental life sciences research and the importance of interdisciplinary collaboration in tackling complex scientific challenges.
【来源】http://www.chinanews.com/life/2024/04-23/10204177.shtml
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