**中国科学家发现白血病新遗传因子，为早期筛查提供新线索**
深圳理工大学（筹）药学院教授赵佳伟与哈佛大学医学院附属波士顿儿童医院的Vijay Sankaran团队近日在《细胞》杂志上发表了一项重大研究。他们利用英国生物样本数据库（UK Biobank）对超过46万个病人样本进行了遗传学分析，成功识别了一个全新的髓系恶性血液肿瘤家族致病风险因子。这一发现有望为早发性白血病的早期筛查和干预提供新的策略和方法。
赵佳伟教授介绍：“目前，治疗白血病的主要方式依赖于健康造血干细胞的移植。然而，非亲属间的造血干细胞配型通常需要长时间的等待，这可能耽误了病人的治疗。”为了找到更有效的预防和治疗策略，研究团队开始深入研究白血病的遗传机制。
经过深入的研究，他们发现了一个新的基因——CTR9。这个基因携带的遗传突变可以使血液肿瘤的易感性增加10倍。更为重要的是，研究团队还揭示了这种突变是如何影响血液肿瘤的发展的。Vijay Sankaran表示：“这些发现为我们提供了一个关于这一基因调控的新视角，使我们有可能通过调控这个基因来预防血液肿瘤。”
英语如下：
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“News Headline: Chinese Scientists Discover New Gene====
“News Headline: Chinese Scientists Discover New Genetic Factor Behind Leukemia
Keywords: Leukemia, Genetic Factor, Screening Intervention
News Content: **Chinese Scientists Discover New Genetic Factor for Leukemia, Offering New Clues for Early Screening**
Zhao Jiawei, a professor at the School of Pharmacy at Shenzhen Tech University (in preparation), and Vijay Sankaran’s team from Boston Children’s Hospital affiliated with Harvard Medical School recently published a major study in the journal “Cell.” They conducted a genetic analysis of over 460,000 patient samples using the UK Biobank database and successfully identified a new family risk factor for myeloid malignant blood tumors. This discovery is expected to provide new strategies and methods for early screening and intervention of early-onset leukemia.
Professor Zhao Jiawei introduced: “Currently, the main treatment for leukemia relies on the transplantation of healthy hematopoietic stem cells. However, hematopoietic stem cell matching between non-relatives usually requires a long wait, which may delay the patient’s treatment.” In order to find more effective prevention and treatment strategies, the research team began to study the genetic mechanism of leukemia in depth.
After in-depth research, they discovered a new gene – CTR9. The genetic mutation carried by this gene can increase the susceptibility of blood tumors by 10 times. More importantly, the research team also revealed how this mutation affects the development of blood tumors. Vijay Sankaran said: “These findings provide us with a new perspective on the regulation of this gene, making it possible for us to prevent blood tumors by regulating this gene.””
【来源】https://www.ithome.com/0/745/114.htm
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