近日，中国科学院过程工程研究所宣布，该所生化工程国家重点实验室主任马光辉院士、魏炜研究员团队开发出具有“纳微复合”多级结构的单剂干粉吸入式疫苗研制平台技术。该技术成功制备了新型干粉吸入式疫苗，并在动物模型上显示出能够高效阻断呼吸道病毒的感染与传播。
该平台技术具有制备速度快、递送效能高、常温易储运、缓释药效长等特点。通过计算分析获得的最佳粒径微米级的疫苗颗粒可直达肺泡、有效沉积，在面对未来新发、突发传染病时，有望实现疫苗的快速构建及高效防治。纳米颗粒表面能够同时展示多种抗原，可以诱导产生广谱免疫应答，扩大了疫苗保护范围。同时，得益于抗原展示的灵活性，该平台也能够迅速、便捷地完成其他呼吸道病毒疫苗的构建。
该技术还能够显著节省储存和运输成本，有助于覆盖冷藏困难等储运条件不足的地区，增加免疫接种率。相关成果论文已经在《自然》杂志上发表。
英文标题：Research team successfully develops new powder inhalation vaccine platform technology
关键词：new powder inhalation vaccine, research platform technology, rapid preparation, long-lasting effect
新闻内容：
A recent announcement from the Institute of Process Engineering, Chinese Academy of Sciences has revealed the development of a single-dose powder inhalation vaccine platform technology by the team of Director of the Institute of Bioengineering and Professor魏炜. This technology has successfully prepared a new powder inhalation vaccine, which has been shown to effectively block the infection and spread of respiratory viruses in animal models.
The platform technology has the characteristics of rapid preparation, efficient delivery, and long-lasting effect. By analyzing the optimal particle size of the vaccine, the researchers have achieved particles that can reach the lungs and effectively deposit, providing efficient protection against respiratory viruses. The surface of the nanoparticles can display multiple antigens simultaneously, inducing a broad immune response and expanding the scope of protection. Additionally, the platform technology can rapidly and easily complete the construction of other respiratory virus vaccines.
The technology can also significantly reduce the cost of storage and transportation, helping to cover areas with refrigeration difficulties and increasing the immunization rate. The related papers have been published in the journal Nature.
【来源】https://www.ithome.com/0/739/686.htm
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